Barcoded Microchips for Biomolecular Assays

Silicon field-effect sensors for biomolecular assays

Applications of laser-polarized 129Xe to biomolecular assays.

The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized 129Xe have motivated the application of 129Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized 129Xe in biomolecular assays that detect ligand-binding events and distinguish protein conformations. The successful application of unfunctionalized and f...

Barcoded Microparticles for Multiplexed Detection

The detection of multiple targets in a single sample is important for many applications, including medical diagnostics, genotyping, and drug discovery. The current approaches to multiplexing, such as planar arrays (such as DNA microarrays) and suspension (particle-based) arrays, require expensive or cumbersome means of encoding, decoding, or functionalizing substrates. Currently, commercially a...

Magnetic barcoded hydrogel microparticles for multiplexed detection.

Magnetic polymer particles have been used in a wide variety of applications ranging from targeting and separation to diagnostics and imaging. Current synthesis methods have limited these particles to spherical or deformations of spherical morphologies. In this paper, we report the use of stop flow lithography to produce magnetic hydrogel microparticles with a graphical code region, a probe regi...

Theranostic barcoded nanoparticles for personalized cancer medicine

Personalized medicine promises to revolutionize cancer therapy by matching the most effective treatment to the individual patient. Using a nanoparticle-based system, we predict the therapeutic potency of anticancer medicines in a personalized manner. We carry out the diagnostic stage through a multidrug screen performed inside the tumour, extracting drug activity information with single cell se...